These are the optimized settings I found and use for my PC running with xp & vista. (You have the right to disagree with me 100%)

- Switch start menu to classic mode. No jazzy menus, so no delay in loading menu .

- Keep desktop background plain and simple. I prefer using black background so that the icons stand out.

- Enable Quick Launch in taskbar.

- Add NOTEPAD & frequently used application shortcuts in quick launch.

- Pay attention to Windows Update & Windows defender scanning. If it prompts update it. Its good practice to keep your system smooth. (Unless you have restriction not to update)

BROWSER Setting

- My work expects me to use IE (which is great ofcourse), keep blank page as startup page.

- Customize the icons and remove the unwanted ones like EDIT, PRINT, MAIL and so on.

- Keep small icons instead of Large icons.

- Organize your favourites menu. Create folders and sub folders under LINKS and move frequently used items under it. It helps me a lot.

- Install Google Toolbar. It helps in better search. Once you start typing, it prompts with previously done searches. (I love this feature)

- Uninstall any unwanted toolbars (i hate the bulky Yahoo & MSN toolbars).
What can you do to improve your efficiency ?

Use both your hands (not just index finger) while typing and selecting menus.

Use mouse to the minimum. (unless you are using some graphical software or doing some audio/video editing)

Use shortcuts as much as you can. (click here to see list of windows shortcuts)

(more to come..)